Efficient and direct nucleophilic difluoromethylation of carbonyl compounds and imines with Me3SiCF2H at ambient or low temperature.

نویسندگان

  • Yanchuan Zhao
  • Weizhou Huang
  • Ji Zheng
  • Jinbo Hu
چکیده

Since 1995, Me(3)SiCF(2)H has been widely believed to be an inefficient difluoromethylating agent, which requires harsh reaction conditions to cleave its rather inert Si-CF(2)H bond. However, it has now been found that, by using a proper Lewis base activator, Me(3)SiCF(2)H can efficiently difluoromethylate various aldehydes, ketones, and imines to give the corresponding products in good to excellent yields at room temperature or even at -78 °C.

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عنوان ژورنال:
  • Organic letters

دوره 13 19  شماره 

صفحات  -

تاریخ انتشار 2011